Technical Physics
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The nitric oxide production in tissues of 7- and 16-week-old rats under mobility restriction
R. I. Zaripova1, G. G. Jafarova1, V. V. Andrianov1,2, Kh. L. Gainutdinov1,2, M.I. Sungatullina1, N.I. Ziyatdinova1, T. L. Zefirov1
1Kazan Federal University, Kazan, Tatarstan, Russia
2Kazan E. K. Zavoisky Physical -Technical Institute (KPhTI), Kazan, Russia
2Kazan E. K. Zavoisky Physical -Technical Institute (KPhTI), Kazan, Russia
Email: ratno1992@mail.ru
The electron paramagnetic resonance method was used to study the intensity of nitric oxide production by analyzing the amount of NO-containing paramagnetic complexes in the heart, liver, and spinal cord tissues of 7- and 16-week-old rats growing under restricted mobility conditions. Nitric oxide production was assessed by the intensity of the EPR signal belonging to the (DETC)2-Fe2+NO complex. The results obtained show that growth under conditions of restricted motility leads to an increase in NO production in all organs under study, with the greatest increase observed in 7-week-old rats. Keywords: nitric oxide, heart, liver, spinal cord, electron paramagnetic resonance.
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