Methods for obtaining polarized xenon for magnetic resonance imaging. Review
Grigoriev G Y1, Lagutin A S1
1National Research Center “Kurchatov Institute”, Moscow, Russia
Email: lagutin_as@nrcki.ru

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A review of experimental studies and design developments of devices for obtaining nuclear-spin hyperpolarized 129Xe by optical pumping of rubidium vapor with subsequent spin exchange with noble gas isotope atoms is presented. Hyperpolarized 129Xe atom is an excellent probe in magnetic resonance imaging in studies of lung structure and function, and biomarkers based on it are applicable for the diagnosis of a wide range of both pulmonary and other diseases. The principles of operation, advantages and disadvantages of polarizer design options are outlined. The main attention is paid to new approaches and technical solutions that determine the trends in the development of the methodology. Keywords: hyperpolarized xenon, lasers, optical pumping, nuclear magnetic resonance, magnetic resonance imaging.
  1. Prikaz MZ RF 8 oktyabrya 1999 . N 363. O razreshenii meditsinskogo primeneniya lekarstvennykh sredstv (1999). (in Russian) https://docs.cntd.ru/document/901746690
  2. Sbornik metodicheskikh rekomendatsiy (pod obschey redaktsiey Potapova A.V.) Primenenie ksenona v klinicheskoy praktike (NKO ASMG, M., 2019) (in Russian)
  3. J.P. Hornak. The Basics of MRI (Rochester Institute of Technology, Rochester, 1996)
  4. H. Marshall, N.J. Stewart, Ho-Fung Chan, M. Rao, G. Norquay, J.M. Wild. Progr. Nucl. Magn, Reson. Spectr., 122, 42 (2021). DOI: 10.1016/j.pnmrs.2020.11.002
  5. D.A. Barskiy, A.M. Coffey, P. Nikolaou, D.M. Mikhaylov, B.M. Goodson, R. Branca, G.J. Lu, M.G. Shapiro, Ville-Veikko Telkki, V.V. Zhivonitko, I.V. Koptyug, O.G. Salnikov, K.V. Kovtunov, V.I. Bukhtiyarov, M. Rosen, M.J. Barlow, S.S. Safavi, I.P. Hall, L. Schroder, E.V. Chekmenev. Chem. A Europ. J., 23 (4), 725 (2017). DOI: 10.1002/chem.201603884
  6. B.M. Goodson, N. Whiting, A.M. Coffey, P. Nikolaou, F. Shi, M.E. Gemeinhardt, R.V. Shchepin, J.G. Skinner, J.R. Birchall, M.J. Barlow, E.Y. Chekmenev. Encyclopedia of Magnetic Resonance, 4, 797 (2015). DOI: 10.1002/9780470034590.emrstm1457
  7. Hyperpolarized 129Xe Magnetic Resonance: Concepts, Production, Techniques and Applications, ed. by T. Meersmann, E. Brunner (Cambridge: Royal Society of Chemistry, 2015)
  8. MRI of the Lung, ed. by H.U. Kauczor, M.O. Wielputz (Springer International Publishing AG, 2018)], DOI: 10.1007/978-3-319-42617-4
  9. M.L. Hirsch, N. Kalechofsky, A. Belzer, M. Rosay, J.G. Kempf. J. Am. Chem. Soc., 137 (26), 8428 (2015). DOI: 10.1021/jacs.5b01252
  10. T.G. Walker, W. Happer. Rev. Modern Phys., 69, 629 (1997). DOI:10.1103/REVMODPHYS.69.629
  11. M. Tamski, J. Milani, C. Roussel, J.-Ph. Ansermet. Phys. Chem. Chem. Phys., 22, 17769 (2020). DOI: 10.1039/d0cp00984a
  12. K.M. Ward, A.H. Aletras, R.S. Balaban. J. Magn. Reson., 143 (1), 79 (2000). DOI: 10.1006/JMRE.1999.1956
  13. K.H. Mok, P. Hore. Methods, 34 (1), 75 (2004). DOI:10.1016/J.YMETH.2004.03.006
  14. R.W. Adams, J.A. Aguilar, A.D. Atkinson, M.J. Cowley, P.I. Elliott, S.B. Duckett, G.G. Green, I.G. Khazal, J. Lopez-Serrano, D.C. Williamson. Science, 323, 1708 (2009). DOI:10.1126/science.1168877
  15. E. Vaneeckhaute, S. De Ridder, J.M. Tyburn, J.G. Kempf, F. Taulelle, J.A. Martens, E. Breynaert. Chem. Phys. Chem., 22 (12), 1150 (2021). DOI: 10.1002/cphc.202100360
  16. J. Brossel, A. Kastler. Comptes Rendus., 229 (23), 1213 (1949)
  17. A. Kastler. J. Phys. Radium, 11 (6), 255 (1950). DOI: 10.1051/jphysrad:01950001106025500
  18. J. Brossel, A. Kastler, J. Winter. J. Phys. Radium, 13 (12), 668 (1952). DOI: 10.1051/jphysrad:019520013012066800
  19. A. Kastler. UFN, 93 (1), 5 (1967) (in Russian) DOI: 10.3367/UFNr.0093.196709b.0005
  20. E.A. Tagirov. Foton. In kn.: Fizicheskiy entsiklopedicheskiy slovar / Gl. red. A.M. Prokhorov (Sov. entsiklopediya, M., 1983) (in Russian) http://es.niv.ru/doc/dictionary/physical/index.htm
  21. G.Yu. Grigoriev, Sh.Sh. Nabiev. Khimicheskaya fizika, 37 (5), 3 (2018) (in Russian). DOI: 10.7868/S0207401X18050011
  22. C.V. Rice, D. Raftery. J. Chem. Phys., 117 (12), 5632 (2002). DOI: 10.1063/1.1500733
  23. W. Happer, E. Miron, S. Schaefer, W.A. Van Wijngaarden, X. Zeng. Phys. Rev. A, 29, 3092 (1984). DOI: 10.1103/PHYSREVA.29.3092
  24. S. Appelt, A. Ben-Amar Baranga, C. Erickson, M.V. Romalis, A.R. Young. Phys. Rev. A, 58 (2), 1412 (1998). DOI: 10.1103/PHYSREVA.58.1412
  25. M. Kelley, R. Branca. J. Appl. Phys., 129, 154901 (2021). DOI: 10.1063/5.0037440
  26. T. Walker. Rev. Modern Phys., 69 (2), 629 (1997). DOI: 10.1103/REVMODPHYS.69.629
  27. Hyperpolarized and Inert Gas MRI: From Technology to Application in Research and Medicine, ed. by M.S. Albert, F.T. Hane (Elsevier, Amsterdam, 2017)
  28. W. Happer. Rev. Modern Phys., 44, 169 (1972). DOI: 10.1103/RevModPhys.44.169
  29. W. Happer, Yuan-Yu Jau, T. Walker. Optically Pumped Atoms. (WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim, 2010)
  30. A.L. Zook, B.B. Adhyaru, C.R. Bowers. J. Magn. Reson., 159 (2), 175 (2002). DOI: 10.1016/s1090-7807(02)00030-7
  31. P. Nikolaou, A.M. Coffey, L.L. Walkup, B.M. Gust, N. Whiting, H. Newton, S. Barcus, I. Muradyan, M. Dabaghyan, G.D. Moroz, M.S. Rosen, S. Patz, M.J. Barlow, E. Chekmenev, B.M. Goodson. Proceed. National Academy Sci. (PNAS), 110 (35), 14150 (2013). DOI: 10.1073/pnas.1306586110
  32. A.S. Khan, R.L. Harvey, J.R. Birchall, R.K. Irwin, P. Nikolaou, G. Schrank, K. Emami, A. Dummer, M.J. Barlow, B.M. Goodson, E.Y. Chekmenev. Angew. Chem. Int. Ed., 60, 22126 (2021). DOI: 10.1002/anie.202015200
  33. B. Driehuys, G.D. Cates, E. Miron, K. Sauer, D.K. Walter, W. Happer. Appl. Phys. Lett., 69, 1668 (1996). DOI: 10.1063/1.117022
  34. U. Ruth, T. Hof, J. Schmidt, D. Fick, H.J. Jansch. Appl. Phys. B, 68, 93 (1999). DOI: 10.1007/S003400050592
  35. Elektronik resurs Rezhim dostupa "INZhEKT Rosatom" Awebdesign Studio, 2020 (in Russian) https://nppinject.ru/produktsiya/ [Date of access: 31 01 2022]
  36. A. Zook, C.R. Bowers. High Capacity Production of > 40% Spin Polarized Xenon-129 for NMR and MRI Applications at the NHMFL. NHMFL Reports Fall 2001 (NHMFL, Florida State University, 2001)
  37. V.I. Bakhmutov. NMR Spectroscopy in Liquids and Solids (CRC Press, N. Y., 2015), DOI: 10.1201/b18341
  38. H. Zhu, I.C. Ruset, F.W. Hersman. Opt. Lett., 30 (11), 1342 (2005). DOI: 10.1364/OL.30.001342
  39. B.L. Volodin, S.V. Dolgy, E.D. Melnik, E. Downs. Opt. Lett., 29 (16), 1891 (2004). DOI: 10.1364/OL.29.001891
  40. N. Whiting, P. Nikolaou, N.A. Eschmann, M.J. Barlow, R. Lammert, J. Ungar, W. Hu, L. Vaissie, B.M. Goodson. Appl. Phys. B, 106 (4), 775 (2012). DOI: 10.1007/S00340-012-4924-X
  41. P. Siddons, C.S. Adams, C. Ge, G. Hughes. J. Phys. B. Atom. Mol. Opt. Phys., 41 (15), 155004 (2008). DOI: 10.1088/0953-4075/41/15/155004
  42. A. Banerjee, D. Das, V. Natarajan. Europhys. Lett., 65 (2), 172 (2004). DOI: 10.1209/EPL/I2003-10069-3
  43. G. Norquay. PhD thesis. Spin-Exchange Optical Pumping and Nuclear Magnetic Resonance of 129Xe. (Sheffield, United Kingdom: Royal Hallamshire Hospital, 2014)
  44. J.G. Skinner. PhD thesis. Optimization of Xenon-Rich Stopped-Flow Spin-Exchange Jptical Pumping for Functional Lung Imaging (Nottingham, University of Nottingham, 2016)
  45. J.R. Birchall, R.K. Irwin, P. Nikolaou, A.M. Coffey, B.E. Kidd, M. Murphy, M. Molway, L.B. Bales, K. Ranta, M. Barlow, B.M. Goodson, M. Rosen, E. Chekmenev. J. Magn. Res., 319, 106813 (2020). DOI: 10.1016/j.jmr.2020.106813
  46. M.S. Freeman. PhD thesis. The Efficiency Limits of Spin Exchange Optical Pumping Methods of 129Xe Hyperpolarization: Implications for in vivo MRI Applications (Duke University, Durham, 2015)
  47. B.C. Anger, G. Schrank, A. Schoeck, K.A. Butle, M.S. Solu, R.J. Pugmire, B. Saam. Phys. Rev. A, 78, 043406 (2008). DOI: 10.1103/PhysRevA.78.043406
  48. S. Breeze, S. Lang, I. Moudrakovski, C. Ratclif. J. Appl. Phys., 87, 8013 (2000). DOI: 10.1063/1.373489
  49. T. Pa asz, L. Mikowskaa, B. G owacz, Z. Olejniczak, M. Suchanek, T. Dohnalik. Acta Phys. Polonica A, 136 (6), 1008 (2019). DOI: 10.12693/APhysPolA.136.1008
  50. L. Repetto, S. Zimmer, F. Allmendinger, P. Blumler, M. Doll, J.O. Grasdijk, W. Heil, K. Jungmann, S. Karpuk, H. Krause, A. Offenhausser, U. Schmidt, Y. Sobolev, L. Willmann. J. Magn. Res., 265, 197 (2016). DOI: 10.1016/j.jmr.2016.02.011
  51. N.N. Kuzma, B. Patton, K. Raman, W. Happer. Phys. Rev. Lett., 88 (14), 147602 (2002). DOI: 10.1103/PHYSREVLETT.88.147602
  52. M. Repetto, P. Blumler, W. Heil, S. Karpuk, K. Tullney, E. Babcock. J. Magn. Res., 252, 187 (2015). DOI: 10.1016/j.jmr.2015.01.015
  53. E.G. Sorte, B.V. Fine, B. Saam. Phys. Rev. B, 85 (17), 174425 (2012). DOI: 10.1103/PhysRevB.85.174425
  54. M.S. Rosen, T.E. Chupp, K.P. Coulter, R.C. Welsh, S.D. Swanson. Rev. Scien. Instrum., 70 (2), 1546 (1999). DOI: 10.1063/1.1149622
  55. N.J. Shah, T. Unlu, H.P. Wegener, H. Halling, R. Zilles, S. Appelt. NMR in Biomedicine, 13 (4), 214 (2000). DOI: 10.1002/1099-1492(200006)13:4<214::AID-NBM634>3.0.CO;2-G
  56. J.C. Leawoods, B.T. Saam, M.S. Conradi. Chem. Phys. Lett., 327, 359 (2000). DOI: 10.1016/S0009-2614(00)00908-8
  57. L.J. Smith, J. Smith, E. Mac Namara, K. Knagge, D. Raftery. J. Phys. Chem. B, 105, 1412 (2001). DOI: 10.1021/JP0032309
  58. C.V. Rice, D. Raftery. J. Chem. Phys., 117 (12), 5632 (2002). DOI: 10.1063/1.1500733
  59. A. Wakai, J. Kershow, K. Nakamura, H. Iida, H. Tamura, Y. Kondon, I. Kanno. Magn. Res. Med. Sci., 2 (4), 189 (2003). DOI: 10.1002/1099-1492(200006)13:4<220::AID-NBM638>3.0.CO;2-F
  60. B. Driehuys, J. Pollaro, G.P. Cofer. Magn. Res. Med., 60 (1), 14 (2008). DOI: 10.1002/mrm.21651
  61. H. Imai, J. Fukutomi, A. Kimura, H. Fujiwara. Concepts in Magnetic Resonance Part B: Magn. Res. Engineer., 33, 192 (2008). DOI: 10.1002/CMR.B.20117
  62. S. Appelt, F.W. Hasing, H. Kuhn, J. Perlo, B. Blumich. Phys. Rev. Lett., 94, 197602 (2005). DOI: 10.1103/PHYSREVLETT.94.197602
  63. X.J. Chen, H.E. Moller, M.S. Chawla, G.P. Cofer, B. Driehuys, L.W. Hedlund, G.A. Johnson. Magn. Res. Med., 42, 721 (1999). DOI: 10.1002/(SICI)1522- 2594(199910)42:4<729::AID-MRM15>3.0.CO;2-2
  64. S. Appelt, T. Unlu, K. Zilles, N.J. Shah, S. Baer-Lang, H. Halling. Appl. Phys. Lett., 75 (3), 427 (1999). DOI: 10.1063/1.124397
  65. R. Seydoux, A. Pines, M. Haake, J.A. Reimer. J. Phys. Chem. B, 103 (22), 4629 (1999). DOI: 10.1021/JP9821984
  66. K. Ruppert, J.R. Brookeman, K.D. Hagspiel, B. Driehuys, J.P. Mugler III. NMR in Biomedicine, 13, 220 (2000). DOI: 10.1002/1099-1492(200006)13:4<220::AID-NBM638>3.0.CO;-F
  67. K. Ruppert, J.R. Brookeman, K.D. Hagspiel, J.P. Mugler III. Magn. Res. Med., 44, 349 (2000). DOI: 10.1002/1522-2594(200009)44:3<349::AID-MRM2>3.0.CO;2-J
  68. T. Meersmann, J.W. Logan, R. Simonutti, S. Caldarelli, A. Comotti, P. Sozzani, L. Kaiser, A. Pines. J. Phys. Chem. A, 104 (50), 11665 (2000). DOI: 10.1021/JP002322V
  69. F.W. Hersman, L.C. Ruset, S. Ketel, I. Muradian, S. Covrig, J. Distelbrink, W. Porter, D. Watt, J. Ketel, J. Brackett, A. Hope, S. Patz. Acad. Radiol., 15 (6), 683 (2008). DOI: 10.1016/j.acra.2007.09.020
  70. A. Asfour. J. Biomed. Sci. Engineer., 03, 1099 (2010). DOI: 10.4236/JBISE.2010.311143
  71. P. Nikolaou, N. Whiting, N.A. Eschmann, K. Chaffee, B.M. Goodson, M. Barlow. J. Magn. Res., 197 (2), 249 (2009). DOI: 10.1016/j.jmr.2008.12.015
  72. Z.I. Cleveland, H.E. Muller, L.W. Hedlund, B. Driehuys. J. Phys. Chem. B, 113 (37), 12489 (2009). DOI: 10.1021/jp9049582
  73. G. Schrank, Z. Ma, A. Schoeck, B. Saam. Phys. Rev. A, 80, 063424 (2009). DOI: 10.1103/PHYSREVA.80.063424
  74. J.S. Six, T. Hughes-Riley, K.F. Stupic, G.E. Pavlovskaya, T. Meersmann. Public Library of Science one (PLOS 1), 7 (11), e49927 (2012). DOI: 10.1371/journal.pone.004992
  75. P. Nikolaou, A.M. Coffey, L.L. Walkup, B.M. Gust, C.D. La Pierre, E. Koehnemann, M.J. Barlow, M.S. Rosen, B.M. Goodson, E.Y. Chekmenev. J. Am. Chem. Soc., 136 (4), 1636 (2014). DOI: 10.1021/ja412093d
  76. J.R. Birchall, R.K. Irwin, M.R.H. Chowdhury, P. Nikolaou, B.M. Goodson, M.J. Barlow, A. Shcherbakov, E.Y. Chekmenev. Anal. Chem., 93 (8), 3883 (2021). DOI: 10.1021/acs.analchem.0c04545
  77. J.R. Birchall, P. Nikolaou, A.M. Coffey, B.E. Kidd, M. Murphy, M. Molway, L.B. Bales, B. Goodson, R.K. Irwin, M.J. Barlow, E.Y. Chekmenev. Anal. Chem., 92 (6), 4309 (2020). DOI: 10.1021/acs.analchem.9b05051
  78. P. Nikolaou, A.M. Coffey, M.J. Barlow, M.S. Rosen, B.M. Goodson, E.Y. Chekmenev. Analyt. Chem., 86 (16), 8206 (2014). DOI: 10.1021/ac501537w
  79. P. Nikolaou, A.M. Coffey, L.L. Walkup, M. Gust, N. Whiting, H. Newton, I. Muradyan, M. Dabaghyan, K. Ranta, G.D. Moroz, M. Rosen, S. Patz, M. Barlow, E. Chekmenev, B.M. Goodson. Magn. Res. Imag., 32 (5), 541 (2014). DOI: 10.1016/j.mri.2014.02.002
  80. W.T. Lee, G. Zheng, C.L. Talbot, X. Tong, T. D'Adam, S. Parnell, M. de Veer, G.R. Polglase, S.B. Hooper, B.R. Thompson, F. Thien, G.F. Egan. Magn. Res. Imag., 79, 112 (2021). DOI: 10.1016/j.mri.2021.02.010
  81. J. Skinner, K. Ranta, A.M. Coffey, P. Nikolaou, M.S. Rosen, E.Y. Chekmenev, P.G. Morris, M.J. Barlow, B.M. Goodson. J. Magn. Res., 312, 06686 (2020). DOI: 10.1016/j.jmr.2020.106686
  82. H. Imai, H. Yoshimura, A. Kimura, H. Fujiwara. Scientific Reports, 7 (1), 7352 (2017). DOI: 10.1038/s41598-017-07695-7
  83. Hyperpolarized Gas MRI for Pulmonary Disease Assessment: Interview with Richard Hullihen, CEO of Polarean Imaging. https://www.medgadget.com/2020/09/hyperpolarized-gas- mri-for-pulmonary-disease-assessment.html. [Date of access: 29.12.2021]
  84. G. Norquay, G.J. Collier, M. Rao, N.J. Stewart, J.M. Wild. Phys. Rev. Lett., 121, 153201 (2018). DOI: 10.1103/PhysRevLett.121.153201
  85. M. Rao, N.J. Stewart, G. Norquay, P.D. Griffiths, J.M. Wild. Magn. Res. Med., 75 (6), 2227 (2016). DOI: 10.1002/mrm.26241
  86. R. Jimenez-Marti nez, D.J. Kennedy, M. Rosenbluh, E. Donley, S. Knappe, S.J. Seltzer, H.L. Ring, V. Bajaj, J. Kitching. Nature Commun., 5, 3905 (2014). DOI: 10.1038/ncomms4908
  87. D.J. Kennedy, S. Seltzer, R. Jimenez-Marti nez, H.L. Ring, N.S. Malecek, S. Knappe, E. Donley, J. Kitching, V. Bajaj, A. Pines. Nature Sci. Reports, 7, 43994 (2017). DOI: 10.1038/srep43994
  88. M. Kelley, A. Burant, R.T. Branca. J. Appl. Phys., 128, 144901 (2020). DOI: 10.1063/5.0019074
  89. H. Fujiwara, H. Imai, A. Kimura. Analytical Sci.: Intern. J. Jpn. Society Analyt. Chem., 35, 869 (2019). DOI: 10.2116/analsci.19P047
  90. C. Chauvin, L. Liagre, C. Boutin, E. Mari, E. Leonce, G. Carret, B. Coltrinari, P. Berthault. Rev. Sci. Instrum., 87, 016105 (2016). DOI: 10.1063/1.4940928
  91. S.E. Korchak, W. Kilian, L. Mitschang. Appl. Magn. Res., 44, 65 (2013). DOI: 10.1007/s00723-012-0425-7
  92. M.S. Freeman, K. Emami, B. Driehuys. Phys. Rev. A, Atomic, Molec., Opt. Phys., 90, 023406 (2014). DOI: 10.1103/PHYSREVA.90.023406
  93. Xenon MRI Platform. https://polarean.com/xenon-mri-platform/\#hyperpolarizer. [Date of access: 28.12.2021]
  94. J.W. Plummer, K. Emami, A. Dummer, J.C. Woods, L.L. Walkup, Z.I. Cleveland. J. Magn. Res., 320, 106845 (2020). DOI: 10.1016/j.jmr.2020.106845
  95. J.M. Wild, H. Marshall, M. Bock, P.M. Jakob, M. Puderbach, F. Molinari, E.J. Van Beek, J. Biederer. Insights Imag., 3, 345 (2012). DOI: 10.1007/s13244-012-0176-x
  96. R. Freeman, R. Smith. Magnetic Resonance in Chemistry and Medicine. (Oxford University Press, Oxford, 2003)
  97. H.U. Kauczor, D. Hofmann, K. Kreitner , H. Nilgens, R. Surkau, W. Weil, A. Potthast, M.V. Knopp, E.W. Otten, M. Thelen. Radiology, 201 (2), 564 (1996). DOI: 10.1148/radiology.201.2.8888259
  98. R. Aysola, E.E. de Lange, M. Castro, T. Altes. J. Magn. Res. Imag., 32, 1379 (2010). DOI: 10.1002/jmri.22388
  99. A.J. Swift, J.M. Wild, S. Fichele, N. Woodhouse, S. Fleming, J. Waterhouse, R. Lawson, M. Paley, E.J. Van Beek. Europ. J. Radiology, 54 (3), 352 (2005). DOI: 10.1016/J.EJRAD.2004.08.002
  100. L. Donnelly, J.R. Mac Fall, H.P. McAdams, J.M. Majura, J. Smith, D.P. Frush, P. Bogonad, H. Charles, C.E. Ravin. Radiology, 212 (3), 885 (1999). DOI: 10.1148/RADIOLOGY.212.3.R99SE20885
  101. F. Hersman, J. Ketel, I. Ruset, S. Ketel, I. Dregely, W. Porter, D. Watt, J. Mugler, T. Altes, K. Ruppert, J. Mata, S. Patz, H. Hatabu, M. Hrovat, I. Muradian, M. Dabaghyan, G. Miller, C. Wang, J. Butler, J. Distelbrin. Proc. Intl. Soc. Mag. Reson. Med., 18 (6), 4598 (2010)
  102. B. Driehuys, S. Martinez-Jimenez, Z. Cleveland, G.M. Metz, D.M. Beaver, J.C. Nouls, S.S. Kaushik, R. Firszt, C. Willis, K.T. Kelly, J. Wolber, M. Kraft, P. Mc Adams. Radiology, 262 (1), 279 (2012). DOI: 10.1148/radiol.11102172
  103. A. Fitterman. Theory and Production of Hyperpolarized Xenon Gas for Lung and Brain (Lakehead University, Orillia, Ontario, 2015)
  104. B. Driehuys, G.P. Cofer, J. Pollaro, J.B. Mackel, L.W. Hedlund, G.A. Johnson. Proc. Natl. Acad. Sci. (PNAS), 103 (48), 18278 (2006). DOI: 10.1073/pnas.0608458103
  105. B. Saam, D. Yablonskiy, V. Kodibagkar, J. Leawoods, J.D. Gierada, J. Cooper, S. Lefrak, M. Conradi. Magn. Reson. Med., 44, 174 (2000). DOI: 10.1002/1522- 2594(200008)44:2<174::aid-mrm2>3.0.co;2-4
  106. S.S. Kaushik, Z.I. Cleveland, G.P. Cofer, G. Metz, D. Beaver, J. Nouls, M. Kraft, W. Auermann, J. Wolber, H.P. McAdams, D. Driehuys. Magn. Res. Med., 65 (4), 1155 (2011). DOI: 10.1002/mrm.22697
  107. J. Grist, M. Chen, G.J. Collier, B. Raman, G. Abu Eid, A. Mc Intyre, V. Matthews, E. Fraser, Ling-Pei Ho, J.M. Wild, F. Gleeson. Radiology, 301 (1), E353 (2021). DOI: 10.1148/radiol.2021210033
  108. H. Li, X. Zhao, Y. Wang, X. Lou, Sh. Chen, H. Deng, L. Shi, J. Xie, D. Tang, J. Zhao, L. Bouchard, L. Xia, X. Zhou. Sci. Adv., 7 (1), eabc8180 (2021). DOI: 10.1126/sciadv.abc8180
  109. L. Schroder, T.J. Lowery, C. Hilty, D.E. Wemmer, A. Pines. Science, 314 (5798), 446 (2006). DOI: 10.1126/science.1131847
  110. Chemical Exchange Saturation Transfer Imaging: Advances and Applications, ed. by M. Mc Mahon, A.A. Gilad, J.W. Bulte, P.C. van Zijl (Pan Stanford Publishing Pte. Ltd, Singapore, 2017), DOI: 10.1201/9781315364421
  111. M. Luhmer, B.M. Goodson, Y.-Q. Song, D.D. Laws, L. Kaiser, M.C. Cyrier, A. Pines. J. American Chem. Society, 121 (24), 3502 (1998). DOI: 10.1021/JA9841916
  112. M. Kunth, C. Witte, L. Schroder. J. Chem. Phys., 141 (19), 194202 (2014). DOI: 10.1063/1.4901429
  113. M. Kunth, C. Witte, L. Schroder. Pharmaceuticals, 14, 79 (2021). DOI: 10.3390/ph14020079
  114. S.D. Zemerov, I. Dmochowski. Royal Society Chem. Adv., 11 (13), 7693 (2021). DOI: 10.1039/D0RA10765D
  115. J. Jayapaul, L. Schroder. Contrast Media Molecular Imag., 2019, 9498173 (2019). DOI: 10.1155/2019/9498173
  116. Positron Emission Tomography, ed. by A. Granov, L. Tiutin, T. Schwarz (Springer- Verlag, Berlin, Heidelberg, 2013), DOI: 10.1007/978-3-642-21120-1.

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