Estimation of the size of SARS-CoV-2 viral particles based on Small-angle X-ray scattering data in the application for SERS spectroscopy
Tabarov A.T.1, Krylov D.A.1, Andreeva O.V.1, Smirnov A.V.1, Danilenko D.M.2, Vitkin V.V.1
1ITMO University, St. Petersburg, Russia
2 Smorodintsev Research Institute of Influenza (a Russian Ministry of Health federal institution), St. Petersburg, Russia
Email: a_t_tabarov@itmo.ru, danilakrylov0@gmail.com
Using small-angle X-ray scattering (SAXS), the pairwise distance function of SARS-CoV-2 viral particles has been determined. The influence of surface proteins, which create a loosened structure on the virus surface, on the results of viral particle size determination is discussed. The obtained results are of interest for the development of selective SERS substrates for the diagnosis of coronavirus infection. Keywords: Viruses, small-angle scattering, X-ray, synchrotron studies.
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