Application of the method of absorption diode laser spectroscopy for measuring the content of 13C and 12C in exhaled air
Kireev S. V.1, Kondrashov A. A.1, Shnyrev S. L. 1
1National Research Nuclear University “MEPhI”, Moscow, Russia
Email: slshnyrev@mephi.ru

PDF
The paper reports on experimental studies of the absorption of 13C16O2 in a mixture with 12C16O2 in exhaled air by laser absorption spectroscopy using a diode laser tunable in the frequency range 4860-4880 cm-1. The results of the studies showed that the minimum detectable concentration of 13C16O2 is at a level of less than 20 ppm, and this approach is promising for measuring the content of 13C16O2 in exhaled air for non-invasive online diagnosis of oncological diseases of the gastrointestinal tract at early stages. Keywords: diode laser spectroscopy, carbon dioxide, breath tests, oncological diseases of the gastrointestinal tract.
  1. R.W. Hulst, B.W. Hoff, A. Ende, G.N.J. Tytgat. Nederlands Tijdschrift Voor Geneeskunde, 143 (8), 395 (1993)
  2. V.T. Ivashkin. Helicobacter pylori: Revolution in gastroenterology (Triad-X, M., 1999), p. 255
  3. L.E. Wroblewski, R.M. Peek, K.T. Wilson. Clin. Microbiol. Rev., 23, 713 (2010). DOI: 10.1128/CMR.00011-10
  4. A.I. Shmak, F.V. Yerzikyan, M.Yu. Revtovich, E.P. Martynov, A.A. Kotov, A.V. Eroshenko. Zdravookhranenie (Minsk), 6, 36 (2018). (in Russian)
  5. V.I. Chissov, V.V. Starinsky, G.V. Petrova. Malignant neoplasms in Russia in 2011 ( Morbidity and mortality) (FSBI "MNIOI named after P.A. Herzen" Ministry of Health of Russia, Moscow, 2013), p. 28
  6. A.S. Loginov, Yu.V. Vasiliev, V.I. Kasyanenko, S.A. Zelenikin. Russian Gastroenterological Journal, 1, 19 (1997)
  7. T.A. Byrne, R.L. Persinger, L.S. Young. Ann. Surg., 222, 243 (1995). DOI: 10.1177/0148607196020005375
  8. P. Greenberg, J. Koch, J. Cello. Am. J. Gastroenterol., 91 (2), 228 (1996)
  9. M. Kato, M. Saito, S. Fukuda. J. Gastroenteol., 39, 629 (2004). DOI: 10.1007/s00535-003-1357-7
  10. E.V. Stepanov. Trudy Instituta Obschey Fiziki RAN im. A.M. Prokhorov, 61, 253 (2005). (in Russian)
  11. S.V. Kireev, A.A. Kondrashov, S.L. Shnyrev, I.G. Simanovsky. Laser Phys., 27 (10), (2017). DOI: 10.1088/1555-6611/aa7549
  12. E.S. Mironchuk, I.V. Nikolaev, V.N. Ochkin, S.S. Rodionova, M.V. Spiridonova, S.N. Tskhai. Kvant. elektron., 39 (4), 388 (2009). (in Russian)
  13. H. Shirin, G. Kenet, O. Shevah, J. Wardi, S. Birkenfeld, M. Shahmurov, R. Bruck, Y. Niv, S.F. Moss, Y. Anvi. Aliment. Pharmacol. Ther., 15 (3), 389 (2001). DOI: 10.1046/j.1365-2036.2001.00926.x
  14. R.G. Plavnik. 13C-urease respiratory test for Helicobacter Pylori ( clinical and organizational aspects) (Medpraktika-M, M., 2017), p. 36
  15. M. Erdely, D. Richter, F.K. Tittel. Appl. Phys. B, 75, 289 (2002). DOI: 10.1007/s00340-002-0960-2
  16. E.I. Korotkova, T.M. Gindullina, N.M. Dubova, O.A. Voronova. Physico-chemical methods of research and analysis (Publishing House of Tomsk Polytechnic University, Tomsk, 2011), p. 177
  17. D.D. Nelson, J.B. McManus, S.C. Herndon, M.S. Zahniser, B. Tuzson, L. Emmenegger. Appl. Phys. B, 90, 301 (2008). DOI: 10.1007/s00340-007-2894-1
  18. D.E. Cooper, R.U. Martinelli, C.B. Carlisle, H. Riris, D.B. Bour, R.J. Menna. Appl. Optics, 32 (33), 6727 (1993). DOI: 10.1364/AO.32.006727
  19. E.V. Stepanov. Diode laser spectroscopy and analysis of biomarker molecules (Fizmatlit, M., 2009), p. 291
  20. S.V. Kireev, A.A. Kondrashov, M.A. Rybakov, S.L. Shnyrev, A.I. Sultangulova. Laser Phys. Lett., 19 (2), 025701 (2022). DOI: 10.1088/1612-202X/ac4590
  21. L.S. Rothman, I.E. Gordon, Y. Babikov, A. Barbe, D. ChrisBenner, P.F. Bernath, M. Birk, L. Bizzocchi, V. Boudon, L.R. Brown, A. Campargue, K. Chance, E.A. Cohen, L.H. Coudert, V.M. Devi, B.J. Drouin, A. Fayt, J.-M. Flaud, R.R. Gamache, J.J. Harrison, J.-M. Hartmann, C. Hill, J.T. Hodges, D. Jacquemart, A. Jolly, J. Lamouroux, R.J. LeRoy, G. Li, D.A. Long, O.M. Lyulin, C.J. Mackie, S.T. Massie, S. Mikhailenko, H.S.P. M?ller, O.V. Naumenko, A.V. Nikitin, J. Orphal, V. Perevalov, A. Perrin, E.R. Polovtseva, C. Richard, M.A.H. Smith, E. Starikova, K. Sung, S. Tashkun, J. Tennyson, G.C. Toon, Vl.G. Tyuterev, G. Wagner. J. Quant. Spectrosc. Radiat. Transfer, 130, 4-50 (2013)
  22. N.V. Smirnov, I.V. Dunin-Barkovsky. Course of probability theory and Mathematical statistics for technical applications (Nauka, M., 1969), p. 511

Подсчитывается количество просмотров абстрактов ("html" на диаграммах) и полных версий статей ("pdf"). Просмотры с одинаковых IP-адресов засчитываются, если происходят с интервалом не менее 2-х часов.

Дата начала обработки статистических данных - 27 января 2016 г.

Publisher:

Ioffe Institute

Institute Officers:

Director: Sergei V. Ivanov

Contact us:

26 Polytekhnicheskaya, Saint Petersburg 194021, Russian Federation
Fax: +7 (812) 297 1017
Phone: +7 (812) 297 2245
E-mail: post@mail.ioffe.ru