The chemical composition of the thermal decomposition products of primary metabolites (large biological molecules) specific to the tissues of tumors of the ear, throat and nose organs was studied using high-resolution terahertz spectroscopy using samples of relatively healthy mucous membranes and neoplasms such as papillomas of the tonsils and larynx and cholesteatomas of the middle ear. A number of compounds of the family of organic acids, aldehydes, nitriles, and other organic compounds have been identified, the absorption lines of which are absent in the spectra of relatively healthy tissues. The potential is shown the possibility of using high-resolution terahertz spectroscopy to analyze the metabolic composition of neoplastic tissues. Keywords: high-resolution spectroscopy, terahertz range, metabolites, ENT-organs.