Volumes and Issues
Home » Optics and Spectroscopy » Year 2024, issue 1 » Article p. 79
<<<>>>
Differentiation of malignant skin neoplasms using Raman spectroscopy with an excitation wavelength of 532 nm in the High-Wavenumber region
Russian version
Shelygina S. N. 1, Rimskaya E. N.1, Timurzieva A. B. 1,2, Saraeva I. N. 1, Kudrin K. G. 1,3, Rupasov A. E. 1, Nastulyavichus A. A. 1
1Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia
2Federal State Budgetary Institution "National Research Institute of Public Health named after N.A. Semashko", Moscow, Russia
3Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University, Moscow, Russia
Email: shelyginasn@lebedev.ru, romehelen@gmail.com, alinko9977z@mail.ru, saraevain@lebedev.ru, kudrin_k@rambler.ru, rupasovan@lebedev.ru, ganuary_moon@mail.ru
PDF
Confocal scanning Raman and fluorescence microspectroscopy are structure-sensitive optical techniques that allow for the non-invasive analysis of biomarkers in skin tissue. Distinct spectral differences were observed in the Raman spectra of basal cell carcinoma and squamous cell carcinoma compared to healthy skin and papilloma. Our analysis of Raman and fluorescence spectra at an excitation wavelength of 532 nm enabled us to propose two spectral criteria: intensity ratios for the bands at 2880 and 1445 cm-1, and for the bands at 2930 and 1445 cm-1. These criteria are based on differences in cell membrane lipid fluctuations, which serve as biomarkers. They allowed for the differentiation of healthy skin from basal cell carcinoma, squamous cell carcinoma, and papilloma with a sensitivity and specificity of more than 90%, demonstrating high clinical significance in the differential diagnosis of skin neoplasms. Keywords: Raman and photoluminescence microspectroscopy, skin cancer, non-invasive diagnostic, spectral analysis.
  1. T. Diepgen, V. Mahler. Br.J. Dermatol., 146 (61), 1-6 (2002). DOI: 10.1046/j.1365-2133.146.s61.2.x
  2. V. Madan, J.T. Lear, R.M. Szeimies. Lancet, 375 (9715), 673-85 (2010). DOI: 10.1016/S0140-6736(09)61196-X
  3. O. Jones, C. Ranmuthu, P.N. Hall, G. Funston, F.M. Walter. Adv Ther., 37 (1), 603-616 (2020). DOI: 10.1007/s12325-019-01130-1
  4. Handbook of Optical Biomedical Diagnostics, ed. by V.V. Tuchin, 2nd ed. (SPIE Press: Bellingham, WA, USA, 2016)
  5. P. Gerami, J.P. Alsobrook, T.J. Palmer, H.S. Robin. J. Am. Acad. Dermatol., 71 (2), 237-44 (2014). DOI: 10.1016/j.jaad.2014.04.042
  6. L.K. Ferris, B. Jansen, J. Ho, K.J. Busam, K. Gross, D.D. Hansen, J.P. Alsobrook 2nd, Z. Yao, G.L. Peck, P. Gerami. JAMA Dermatol., 153 (7), 675-80 (2017). DOI: 10.1001/jamadermatol.2017.0473
  7. C.J. Cockerell, J. Tschen, S.D. Billings, C. Rock, B. Evans, L. Clarke. J. Am. Acad. Dermatol., 72 (5), AB3-AB3 (2015). DOI: 10.1016/j.jaad.2015.02.020
  8. H. Skvara, L. Teban, M. Fiebiger, M. Binder, H. Kittler. Arch. Dermatol., 141 (2), 155-160 (2005)
  9. H.D. Heibel, L. Hooey, C.J. Cockerell. Am. J. Clin. Dermatol., 21 (4), 513-524 (2020). DOI: 10.1007/s40257-020-00517-z
  10. Handbook of Non-Invasive Methods and the Skin, 2nd ed., ed. by J. Serup, G.B.E. Jemec, G.L. Grove (CRC Press: Boca Raton, FL, USA, 2006)
  11. N.N. Potekaev, E.K. Shuginina, T.S. Kuzmina, L.S. Arutyunyan. Dermatoskopiya v klinicheskoy praktike. Rukovodstvo dlya vrachey (MDV, M.,2011) (in Rissian)
  12. A. Haroon, S. Shaf, B.K. Rao. Dermatol. Clin., 35 (4), 457-64 (2017). DOI: 10.1016/j.det.2017.06.007
  13. G. Monheit, A.B. Cognetta, L. Ferris, H. Rabinovitz, K. Gross, M. Martini, J.M Grichnik, M. Mihm, V.G. Prieto, P. Googe, R. King, A. Toledano, N. Kabelev, M. Wojton, D. Gutkowicz-Krusin. Arch. Dermatol., 147 (2), 188-94 (2011). DOI: 10.1001/archdermatol.2010.302
  14. L. Matveev, V. Zaitsev, G. Gelikonov, A. Matveyev, A. Moiseev, S. Ksenofontov, V. Gelikonov, M. Sirotkina, N. Gladkova, V. Demidov, A. Vitkin. Optics Lett., 40 (7), 1472-1475 (2015). DOI: 10.1364/OL.40.001472
  15. S.A. Alawi, M. Kuck, C. Wahrlich, S. Batz, G. Mckenzie, J.W. Fluhr, J. Lademann, M. Ulrich. Exp. Dermatol., 22 (8), 547-51 (2013). DOI: 10.1111/exd.12196
  16. L. Themstrup, C.A. Banzhaf, M. Mogensen, G.B.E. Jemec. Photodiagn Photodyn Ther., 11 (1), 7-12 (2014). DOI: 10.1016/j.pdpdt.2013.11.003
  17. Multimodal optical diagnostics of cancer, ed. by V.V. Tuchin, J. Popp, V.P. Zakharov, (Springer Nature Switzerland AG, Basel, 2020)
  18. Y. Surkov, I. Serebryakova, Y. Kuzinova, O. Konopatskova, D. Safronov, S. Kapralov, E. Genina, V. Tuchin. Diagnostics, 14 (2), 202 (2024). DOI: 10.3390/diagnostics14020202
  19. C. Kendall, J. Hutchings, H. Barr, N. Shepherd, N. Stone. Faraday Discuss, 149 (1), 279-90 (2011). DOI: 10.1039/c005379a
  20. Z. Huang, S.K. Teh, W. Zheng, K. Lin, K. Y. Ho, M. Teh, K.G. Yeoh. Biosens Bioelectron, 26 (2), 383-9 (2010). DOI: 10.1016/j.bios.2010.07.125
  21. N.D. Magee, J.R. Beattie, C. Carland, R. Davis, K. McManus, I. Bradbury, D.A. Fennell, P.W. Hamilton, M. Ennis, J.J. McGarvey, J.S. Elborn. J. Biomed. Opt., 15 (2), 026015 (2010). DOI: 10.1117/1.3323088
  22. J.F. Brennan, T.J. Romer, R.S. Lees, A.M. Tercyak, J.R. Kramer Jr., M.S. Feld. Circulation, 96 (1), 99-105 (1997). DOI: 10.1161/01.cir.96.1.99
  23. J. Zhang, Y. Fan, Y. Song, J. Xu. Medicine, 97 (34), e12022 (2018). DOI: 10.1097/MD.0000000000012022
  24. B. Yakimov, E. Shirshin, J. Schleusener, A. Allenova, V. Fadeev, M. Darvin. Sci. Rep., 10 (1), 14374 (2020). DOI: 10.1038/s41598-020-71220-6
  25. A. Sdobnov, M. Darvin, J. Schleusener, J. Lademann, V. Tuchin. J. Biophotonics, 12 (5), e201800283 (2018). DOI: 10.1002/jbio.201800283
  26. A. Cios, M. Ciepielak, . Szymanski, A. Lewicka, S. Cierniak, W. Stankiewicz, M. Mendrycka, S. Lewicki. Int. J. Mol. Sci., 22 (5), 2437 (2021). DOI: 10.3390/ijms22052437
  27. I. Bratchenko, L. Bratchenko, A. Moryatov, Y. Khristoforova, D. Artemyev, O. Myakinin, A. Orlov, S. Kozlov, V. Zakharov. Experimental Dermatology, 30 (5), 652-663 (2021). DOI: 10.1111/exd.14301
  28. Z. Wu, B. Deng, Y. Zhou, H. Xie, Y. Zhang, L. Lin, J. Ye. Advanced Science, 10 (24), 2301721 (2023). DOI: 10.1002/advs.202301721
  29. E. Rimskaya, S. Shelygina, A. Timurzieva, I. Saraeva, E. Perevedentseva, N. Melnik, K. Kudrin, D. Reshetov, S. Kudryashov. Int. J. Mol. Sci., 24 (19), 14748 (2023). DOI: 10.3390/ijms241914748
  30. Z. Movasaghi, S. Rehman, I.U. Rehman. Appl. Spectroscopy Rev., 42 (5), 493-541 (2007). DOI: 10.1080/05704920701551530
  31. C. Choe, J. Lademann, M.E. Darvin. Analyst, 141 (22), 6329-6337 (2016). DOI: 10.1039/C6AN01717G
  32. F. Leon-Bejarano, M.O. Mendez, M.G. Rami rez-Eli as, A. Alba. Appl. Spectrosc., 73 (12), 1436-1450 (2019). DOI: 10.1177/0003702819860121
  33. N.J. Kline, P.J. Treado. J. Raman Spectroscopy, 28 (2-3), 119-124 (1997). DOI: 10.1002/(SICI)1097-4555 (199702)28:2/3<119::AID-JRS73>3.0.CO;2-3
  34. C. Camerlingo, I. Delfino, G. Perna, V. Capozzi, M. Lepore. Sensors, 11 (9), 8309-8322 (2011). DOI: 10.3390/s110908309

Подсчитывается количество просмотров абстрактов ("html" на диаграммах) и полных версий статей ("pdf"). Просмотры с одинаковых IP-адресов засчитываются, если происходят с интервалом не менее 2-х часов.

Дата начала обработки статистических данных - 27 января 2016 г.

Publisher:

Ioffe Institute

Institute Officers:

Director: Sergei V. Ivanov

Contact us:

26 Polytekhnicheskaya, Saint Petersburg 194021, Russian Federation
Fax: +7 (812) 297 1017
Phone: +7 (812) 297 2245
E-mail: post@mail.ioffe.ru